Article
Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane.
Molecular biology of the cell - 1 Jun 2005
Burri Lena, Strahm Yvan, Hawkins Christine J, Gentle Ian E, Puryer Michelle A, Verhagen Anne, Callus Bernard, Vaux David, Lithgow Trevor
Abstract excerpt
DIABLO/Smac is a mitochondrial protein that can promote apoptosis by promoting the release and activation of caspases. To do so, DIABLO/Smac must first be processed by a mitochondrial protease and then released into the cytosol, and we show this in an intact cellular system. We propose that the precursor form of DIABLO/Smac enters the mitochondria through a stop-transfer pathway and is processed to its active...
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