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Article

AUG sequences are required to sustain nonsense-codon-mediated suppression of splicing.

Nucleic acids research - 1 Jan 2006

Kamhi Eyal, Yahalom Galit, Kass Gideon, Hacham Yael, Sperling Ruth, Sperling Joseph

Abstract excerpt

More than 90% of human genes are rich in intronic latent 5' splice sites whose utilization in pre-mRNA splicing would introduce in-frame stop codons into the resultant mRNAs. We have therefore hypothesized that suppression of splicing (SOS) at latent 5' splice sites regulates alternative 5' splice site selection in a way that prevents the production of toxic nonsense mRNAs and verified this idea by showing that...

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Identifiers

PMID: 16855285
DOI: 10.1093/nar/gkl390
PMCID: PMC1524910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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