Article
A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degeneration.
Neuroscience letters - 29 Mar 2002
Lavedan Christian, Buchholtz Stephanie, Nussbaum Robert L, Albin Roger L, Polymeropoulos Mihael H
Abstract excerpt
Parkinson's disease (PD) is a common neurodegenerative movement disorder characterized by the destruction of dopaminergic neurons of the substantia nigra. We have identified a new mutation (Gly336Ser) in the medium neurofilament subunit in a patient of French-Canadian origin with early onset severe PD. This finding suggests, for the first time, that aberrations in neuronal molecules involved in the cytoskeleton...
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