Article
Mutation analysis of the neurofilament M gene in Parkinson's disease.
Neuroscience letters - 13 Nov 2003
Krüger Rejko, Fischer Christian, Schulte Thorsten, Strauss Karsten M, Müller Thomas, Woitalla Dirk, Berg Daniela, Hungs Marcel, Gobbele Rene, Berger Klaus, Epplen Jörg T, Riess Olaf, Schöls Ludger
Abstract excerpt
Neurofilament M, a major component of Lewy bodies, represents an interesting candidate in the pathogenesis of Parkinson's disease (PD). We performed detailed mutation analyses of the NF-M gene in 322 familial and sporadic PD patients. Two polymorphisms (Ala475Thr and Gly697Arg) occurred at similar frequencies in PD patients and controls. A Pro725Gln substitution and a deletion of valine in position 829 were...
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