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Article

Recombinant variant fibrinogens substituted at residues gamma326Cys and gamma339Cys demonstrated markedly impaired secretion of assembled fibrinogen.

Thrombosis research - 1 Jul 2009

Haneishi Ayumi, Terasawa Fumiko, Fujihara Noriko, Yamauchi Kazuyoshi, Okumura Nobuo, Katsuyama Tsutomu

Abstract excerpt

BACKGROUND: To study the functions of residues gamma326Cys and gamma339Cys in the assembly and/or secretion of fibrinogen, recombinant fibrinogens were synthesized to replicate naturally occurring gamma326Tyr and gamma326Ser variants, along with gamma326Ala and gamma339Ala variants. METHODS: A fibrinogen gamma-chain expression vector was altered and transfected into Chinese hamster ovary (CHO) cells. Cell lysates...

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Identifiers

PMID: 19419756
DOI: 10.1016/j.thromres.2009.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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