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Article

Comparison of molecular structure and fibrin polymerization between two Bβ-chain N-terminal region fibrinogen variants, Bβp.G45C and Bβp.R74C.

International journal of hematology - 1 Sept 2020

Kaido Takahiro, Yoda Masahiro, Kamijo Tomu, Taira Chiaki, Higuchi Yumiko, Okumura Nobuo

Abstract excerpt

We identified two heterozygous dysfibrinogenemias, Bβp.Gly45Cys (Kyoto VII; K-VII) and Bβp.Arg74Cys (Iida II; I-II). The impairment of polymerization of Bβp.G45C has been well analyzed; however, that of Bβp.R74C has not. Thus, we compared fibrin polymerization between these variants. To determine the structural and functional characterization of purified fibrinogens, we performed immunoblotting analysis, kinetic...

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PMID: 32562089
DOI: 10.1007/s12185-020-02919-5

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