Article
Mutation screening of the BRCA1 gene in Slovak patients.
Neoplasma - 1 Jan 2001
Tomka M, Sedlakova O, Reinerova M, Veselovska Z, Stevurková V, Bartosová Z, Zajac V
Abstract excerpt
Breast cancer is the most commonly observed malignancy in women of the western world. The family history is the strongest risk factor for the disease. Two major genes, BRCA1 and BRCA2 that are involved in the familial breast and ovarian cancer have been described. Germ-line mutations of the BRCA1 gene have been linked to 85% of all hereditary breast and ovarian cancers. We performed a mutation screening ofthe...
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