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Screening of 1331 Danish breast and/or ovarian cancer families identified 40 novel BRCA1 and BRCA2 mutations.

Familial cancer - 1 Jun 2011

Hansen Thomas V O, Jønson Lars, Steffensen Ane Y, Andersen Mette K, Kjaergaard Susanne, Gerdes Anne-Marie, Ejlertsen Bent, Nielsen Finn C

Abstract excerpt

Germ-line mutations in the tumour suppressor genes BRCA1 and BRCA2 predispose to breast and ovarian cancer. Since 1999 we have performed mutational screening of breast and/or ovarian cancer patients in East Denmark. During this period we have identified 40 novel sequence variations in BRCA1 and BRCA2 in high risk breast and/or ovarian cancer families. The mutations were detected via pre-screening using dHPLC or...

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Source

Identifiers

PMID: 21318380
DOI: 10.1007/s10689-011-9422-5

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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