Article
Genotype resistance profiles in patients failing an NNRTI-containing regimen, and modifications after stopping NNRTI therapy.
Journal of clinical laboratory analysis - 1 Jan 2002
Quiros-Roldan Eugenia, Airoldi Monica, Moretti Francesca, Fausti Caterina, Pan Angelo, Casari Salvatore, Torti Carlo, Castelli Francesco, Carosi Giampiero
Abstract excerpt
Resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) develops quickly and independently if they are used in combination with NRTIs or protease inhibitors (PIs) as rescue therapy, mainly due to the low genetic barrier of this class of drugs. In this study we examined clinical, therapeutic, and virologic characteristics in 88 patients with mutations conferring resistance to NNRTIs, and in 11...
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