Article
The effect of number of mutations and of drug-class sparing on virological response to salvage genotype-guided antiretroviral therapy.
Antiviral therapy - 1 Dec 2003
Ciancio Bruno Christian, Trotta Maria Paola, Lorenzini Patrizia, Forbici Federica, Visco-Comandini Ubaldo, Gori Caterina, Bonfigli Sandro, Bellocchi Maria Concetta, Sette Pietro, D'Arrigo Roberta, Tozzi Valerio, Zaccarelli Mauro, Boumis Evangelo, Narciso Pasquale, Perno Carlo Federico, Antinori Andrea
Abstract excerpt
OBJECTIVE: To assess on longitudinal data the impact of number of drug-associated mutations at genotype resistance testing (GRT) and history of previous exposure to antiretrovirals on the virological response to genotype-guided antiretroviral therapy. METHODS: Subjects that failed HAART who underwent GRT between June 1999 and March 2002 were enrolled. GRT was performed by Viroseq-2 with expert advice offered to...
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