Article
Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm.
Developmental biology - 15 Apr 2002
Carmena Ana, Buff Eugene, Halfon Marc S, Gisselbrecht Stephen, Jiménez Fernando, Baylies Mary K, Michelson Alan M
Abstract excerpt
Convergent intercellular signals must be precisely integrated in order to elicit specific biological responses. During specification of muscle and cardiac progenitors from clusters of equivalent cells in the Drosophila embryonic mesoderm, the Ras/MAPK pathway--activated by both epidermal and fibroblast growth factor receptors--functions as an inductive cellular determination signal, while lateral inhibition...
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