Article
Does a retrograde response in human aging and longevity exist?
Experimental gerontology - 1 Sept 2000
De Benedictis G, Carrieri G, Garasto S, Rose G, Varcasia O, Bonafè M, Franceschi C, Jazwinski S M
Abstract excerpt
The retrograde response (RR) is a compensatory mechanism by which mutant strains of yeast are able to cope with mitochondrial DNA (mtDNA) impairments by up-regulating the expression of the stress-responder nuclear genes and significantly increasing lifespan. Starting from the observation that both mtDNA variability and Tyrosine hydroxylase (THO, stress-responder gene) variability are correlated with human...
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