Article
Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?
PloS one - 11 Apr 2011
Beristain Alexander G, Zhu Hua, Leung Peter C K
Abstract excerpt
Metastatic carcinoma cells exploit the same molecular machinery that allows human placental cytotrophoblasts to develop an invasive phenotype. As altered expression levels of ADAMTS (ADisintegrin And Metalloproteinase with ThromboSpondin repeats) subtypes have been associated with cancer progression, we have examined the function and regulation of members of this gene family in epithelial cell invasion using...
Topics
- ADAM Proteins
- ADAMTS Proteins
- Cell Aggregation
- Cell Line
- Cell Movement
- Epithelial Cells
- Extracellular Matrix
- Female
- Focal Adhesion Protein-Tyrosine Kinases
- Gene Expression Regulation, Enzymologic
- Gene Silencing