Article
Association between AAAG repeat polymorphism in the P3 promoter of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene and adult height, urinary pyridinoline excretion, and promoter activity.
The Journal of clinical endocrinology and metabolism - 1 Apr 2002
Minagawa Masanori, Yasuda Toshiyuki, Watanabe Tomoyuki, Minamitani Kanshi, Takahashi Yoshihito, Goltzman David, White John H, Hendy Geoffrey N, Kohno Yoichi
Abstract excerpt
The PTH/PTHrP receptor (PTHR1) plays an essential role in skeletal development and mediates many other functions of PTH and PTHrP. Human PTHR1 gene transcription is controlled by three promoters, P1-P3. The most proximal promoter, P3, is active in bone and osteoblast-like cell lines and accounts for the majority of renal transcripts in adults. We have identified a tetranucleotide repeat (AAAG)n polymorphism in...
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