Article
Regulation of human CYP11B2 and CYP11B1: comparing the role of the common CRE/Ad1 element.
Endocrine research - 1 Nov 2000
Bassett M H, Zhang Y, White P C, Rainey W E
Abstract excerpt
In humans, the final steps in corticosteroid production results from the activity of aldosterone synthase in the glomerulosa and 11beta-hydroxylase in the fasciculata. The regional expression of these isozymes is believed to result from transcriptional regulation of the aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) genes. Previous studies suggest that the primary cis-element needed for agonist...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
