Article
Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins.
The Biochemical journal - 1 Jul 2002
Ghys Karen, Fransen Marc, Mannaerts Guy P, Van Veldhoven Paul P
Abstract excerpt
Pex7p is a WD40-containing protein involved in peroxisomal import of proteins containing an N-terminal peroxisome-targeting signal (PTS2). The interaction of human recombinant Pex7p expressed in different hosts/systems with its PTS2 ligand and other peroxins was analysed using various experimental approaches. Specific binding of human Pex7p to PTS2 could be demonstrated only when Pex7p was formed in vitro by a...
Topics
- Animals
- Base Sequence
- CHO Cells
- Chondrodysplasia Punctata, Rhizomelic
- Cricetinae
- Genetic Complementation Test
- Humans
- Membrane Proteins
- Mice
- Peroxisomal Biogenesis Factor 2
- Peroxisomal Targeting Signal 2 Receptor
- Peroxisomes
- Phenotype