Article
Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2001
Matesic L E, Yip R, Reuss A E, Swing D A, O'Sullivan T N, Fletcher C F, Copeland N G, Jenkins N A
Abstract excerpt
The d, ash, and ln coat color mutations provide a unique model system for the study of vesicle transport in mammals. All three mutant loci encode genes that are required for the polarized transport of melanosomes, the specialized, pigment-containing organelles of melanocytes, to the neighboring keratinocytes and eventually into coat hairs. Genetic studies suggest that these genes function in the same or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.