Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

doi:10.1074/jbc.M202684200

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Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

The Journal of biological chemistry - 21 Jun 2002

Schwientek Tilo, Bennett Eric P, Flores Carlos, Thacker John, Hollmann Martin, Reis Celso A, Behrens Jane, Mandel Ulla, Keck Birgit, Schäfer Mireille A, Haselmann Kim, Zubarev Roman, Roepstorff Peter, Burchell Joy M, Taylor-Papadimitriou Joyce, Hollingsworth Michael A, Clausen Henrik

Abstract excerpt

The completed fruit fly genome was found to contain up to 15 putative UDP-N-acetyl-alpha-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-transferase) genes. Phylogenetic analysis of the putative catalytic domains of the large GalNAc-transferase enzyme families of Drosophila melanogaster (13 available), Caenorhabditis elegans (9 genes), and mammals (12 genes) indicated that distinct...

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PMID: 11925450
DOI: 10.1074/jbc.M202684200

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