Article
TP53 genotype but not p53 immunohistochemical result predicts response to preoperative short-term radiotherapy in rectal cancer.
Annals of surgery - 1 Apr 2002
Kandioler Daniela, Zwrtek Ronald, Ludwig Carmen, Janschek Elisabeth, Ploner Meinhard, Hofbauer Friedrich, Kührer Irene, Kappel Sonja, Wrba Friedrich, Horvath Manfred, Karner Josef, Renner Karl, Bergmann Michael, Karner-Hanusch Judith, Pötter Richard, Jakesz Raimund, Teleky Bela, Herbst Friedrich
Abstract excerpt
OBJECTIVE: To evaluate and compare the predictive power of p53 gene analysis versus p53 immunohistochemical staining in terms of response to preoperative short-term radiotherapy using 25 Gy in operable rectal cancer. SUMMARY BACKGROUND DATA: Recent studies show that p53 may be a determinant of radiosensitivity being required for induction of apoptosis in case of radiation-induced DNA damage. METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.