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Article

MYC Expression Promotes the Proliferation of Neural Progenitor Cells in Culture and In Vivo

1 Jan 2002

Abstract excerpt

Primitive neuroectodermal tumors (PNETs) are pediatric brain tumors that result from defects in signaling molecules governing the growth and differentiation of neural progenitor cells. We used the RCAS-TVA system to study the growth effects of three genetic alterations implicated in human PNETs on a subset of neural progenitor cells that express the intermediate filament protein, nestin. The genetic alterations...

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PMID: 11922389
DOI: 10.1038/sj.neo.7900200

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