Article
Characterization of five new cell lines derived from human primitive neuroectodermal tumors of the central nervous system.
Cancer research - 15 Jun 1994
Pietsch T, Scharmann T, Fonatsch C, Schmidt D, Ockler R, Freihoff D, Albrecht S, Wiestler O D, Zeltzer P, Riehm H
Abstract excerpt
Medulloblastoma (MB) represents the most frequent malignant brain tumor of childhood but only a few cell lines and animal models of this primitive neuroectodermal tumor (PNET) have thus far been established. Using specific cell culture conditions, we were able to derive four human MB cell lines (MHH-MED-1-4) as well as a cell line from a spinal PNET (MHH-PNET-5). The four MB cell lines grew in suspension as...
Topics
- Animals
- Cell Division
- Cerebellar Neoplasms
- Genotype
- Humans
- Immunohistochemistry
- Karyotyping
- Medulloblastoma
- Mice
- Mice, Nude
- Neoplasm Transplantation