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Article

Deletion of RUNX1 exons 1 and 2 associated with familial platelet disorder with propensity to acute myeloid leukemia.

Cancer genetics - 1 Apr 2018

Cavalcante de Andrade Silva Marcela, Krepischi Ana Cristina Victorino, Kulikowski Leslie Domenici, Zanardo Evelin Aline, Nardinelli Luciana, Leal Aline Medeiros, Costa Silvia Souza, Muto Nair Hideki, Rocha Vanderson, Velloso Elvira Deolinda Rodrigues Pereira

Abstract excerpt

Familial platelet disorder with propensity to acute myeloid leukemia (FPD/AML) associated with RUNX1 mutations is an autosomal dominant disorder included in the group of the myeloid neoplasms with germ line predisposition. We describe two brothers who were diagnosed with hematological malignancies (one with AML and the other with T-cell lymphoblastic lymphoma). There was a history of leukemia in the paternal...

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Source

Identifiers

PMID: 29666006
DOI: 10.1016/j.cancergen.2018.01.002

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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