Article
Use of supplementary phenotype to identify additional rheumatoid arthritis loci in a linkage analysis of 342 UK affected sibling pair families.
BMC medical genetics - 21 Dec 2009
Tayo Bamidele O, Liang Yulan, Kelemen Arpad, Miller Austin, Trevisan Maurizio, Cooper Richard S
Abstract excerpt
BACKGROUND: Although rheumatoid arthritis has been shown to have moderately strong genetic component, both linked loci identified in linkage analyses and susceptibility variants from association studies are short of adequately accounting for a comprehensive catalogue of the molecular factors underlying this complex disease. The objective of this study was to use supplementary phenotype based on cumulative hazard...
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