Article
Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.
The hematology journal : the official journal of the European Haematology Association - 1 Jan 2001
Puccetti E, Sennewald B, Fosca-Ferrara F, Boehrer S, Bianchini A, Hoelzer D, Ottmann O G, Nervi C, Ruthardt M
Abstract excerpt
INTRODUCTION: Acute promyelocytic leukemia (APL) patients with t(15;17)(PML/RARalpha positive) achieve remission upon t-RA treatment, whereas patients with t(11;17)(PLZF/RARalpha positive) do not. Both APL translocation products bind to the histone deacetylase (HD)-recruiting nuclear co-repressor complex (HD-NCR) in a ligand-dependent manner through their RARalpha portion. Differently to PML/RARalpha,...
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