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Characterization of Two Novel Pyrogenic Toxin Superantigens Made by an Acute Rheumatic Fever Clone ofStreptococcus pyogenesAssociated with Multiple Disease Outbreaks

18 Nov 2002

Abstract excerpt

The pathogenesis of acute rheumatic fever (ARF) is poorly understood. We identified two contiguous bacteriophage genes, designated speL and speM, encoding novel inferred superantigens in the genome sequence of an ARF strain of serotype M18 group A streptococcus (GAS). speL and speM were located at the same genomic site in 33 serotype M18 isolates, and no nucleotide sequence diversity was observed in the 33...

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PMID: 12438391
DOI: 10.1128/iai.70.12.7095-7104.2002

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