Article
Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism.
Hepatology (Baltimore, Md.) - 1 Apr 2002
Kaplan Michael, Hammerman Cathy, Rubaltelli Firmino F, Vilei Maria T, Levy-Lahad Ephrat, Renbaum Paul, Vreman Hendrik J, Stevenson David K, Muraca Maurizio
Abstract excerpt
Hemolysis may contribute to hyperbilirubinemia in Gilbert's syndrome. The authors examined blood carboxyhemoglobin corrected for inspired CO (COHbc) to index heme catabolism and serum conjugated bilirubin fractions to reflect bilirubin conjugation. Both parameters were related to UDP-glucuronosyltransferase 1A1 (UGT) promoter polymorphism, associated with Gilbert's syndrome, in term male newborns. COHbc was...
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