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Article

Genotoxicity study of a new tetraalkylammonium derivative of 6-methyluracil (agent No. 547).

Archives of toxicology - 1 Mar 2002

Karamova Nazira S, Ivanchenko Olga B, Ilinskaya Olga N, Zobov Vladimir V, Reznik Vladimir S

Abstract excerpt

Agent No. 547 (1,3-bis[omega-(diethyl-ortho-nitrobenzylammonio)-pentyl]-6-methyluracil dibromide), a newly synthesized inhibitor of mammalian-specific acetyltcholinesterase (EC 3.1.1.7) was investigated for genotoxicity using the DNA-repair test, Ames test and in vivo micronucleus test with mouse peripheral blood erythrocytes. Agent No. 547 did not cause significant changes in growth of repair-deficient...

Topics

Animals
Cholinesterase Inhibitors
DNA Repair
Dose-Response Relationship, Drug
Erythrocytes
Escherichia coli
In Vitro Techniques
Male
Mice
Mice, Inbred CBA
Micronucleus Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsomes, Liver

Mutagens

Mutation

Salmonella typhimurium

Uracil

Source

Identifiers

PMID: 11914783
DOI: 10.1007/s00204-001-0302-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11914783-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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