Article
Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance.
The Plant cell - 1 Mar 2002
Morel Jean-Benoit, Godon Christian, Mourrain Philippe, Béclin Christophe, Boutet Stéphanie, Feuerbach Frank, Proux Florence, Vaucheret Hervé
Abstract excerpt
Transgene-induced post-transcriptional gene silencing (PTGS) results from specific degradation of RNAs that are homologous with the transgene transcribed sequence. This phenomenon, also known as cosuppression in plants and quelling in fungi, resembles RNA interference (RNAi) in animals. Indeed, cosuppression/quelling/RNAi require related PAZ/PIWI proteins (AGO1/QDE-2/RDE-1), indicating that these mechanisms are...
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