Article
Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line.
Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002
Baruch Dror I, Gamain Benoit, Barnwell John W, Sullivan JoAnn S, Stowers Anthony, Galland G Gale, Miller Louis H, Collins William E
Abstract excerpt
Immunity to Plasmodium falciparum in African children has been correlated with antibodies to the P. falciparum erythrocyte membrane protein 1 (PfEMP1) variant gene family expressed on the surface of infected red cells. We immunized Aotus monkeys with a subregion of the Malayan Camp variant antigen (MCvar1) that mediates adhesion to the host receptor CD36 on the endothelial surface and present data that PfEMP1 is...
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