Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overproduction of a P450 that metabolizes diazinon is linked to a loss-of-function in the chromosome 2 ali-esterase (MdalphaE7) gene in resistant house flies.

Insect molecular biology - 1 Dec 2001

Sabourault C, Guzov V M, Koener J F, Claudianos C, Plapp F W, Feyereisen R

Abstract excerpt

Up-regulation of detoxifying enzymes in insecticide-resistant strains of the house fly is a common mechanism for metabolic resistance. However, the molecular basis of this increased insecticide metabolism is not well understood. In the multiresistant Rutgers strain, several cytochromes P450 and glutathione S-transferases are constitutively overexpressed at the transcriptional level. Overexpression is the result...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carboxylesterase
Share to Carboxylic Ester Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Genes, Insect

Share to Glycine

Share to Houseflies

Share to Insecticide Resistance

Share to Point Mutation

Source

Identifiers

PMID: 11903631
DOI: 10.1046/j.0962-1075.2001.00303.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overproduction of a P450 that metabolizes diazinon is linked to a loss-of-function in the chromosome 2 ali-esterase (MdalphaE7) gene in resistant house flies.PMID 11903631Read ↗

Cytochrome P450 monooxygenases and insecticide resistance in insects.Semantic proximity Read ↗

A single p450 allele associated with insecticide resistance in Drosophila.Semantic proximity Read ↗

A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly.Semantic proximity Read ↗

Evolutionary changes in gene expression, coding sequence and copy-number at the Cyp6g1 locus contribute to resistance to multiple insecticides in Drosophila.Semantic proximity Read ↗

Genomic and Transcriptomic Associations Identify a New Insecticide Resistance Phenotype for the Selective Sweep at the Cyp6g1 Locus of Drosophila melanogaster.Semantic proximity Read ↗

Multiple mutations and overexpression of the MdaE7 carboxylesterase gene associated with male-linked malathion resistance in housefly, Musca domestica (Diptera: Muscidae).Semantic proximity Read ↗

Functional characterization of cytochrome P450s associated with pyrethroid resistance in the olive fruit fly <i>Bactrocera oleae</i>Semantic proximity Read ↗

Identification of SNPs involved in regulating a novel alternative transcript of P450 CYP6ER1 in the brown planthopper.Semantic proximity Read ↗

Partitioning the roles of CYP6G1 and gut microbes in the metabolism of the insecticide imidacloprid in Drosophila melanogaster.Semantic proximity Read ↗

Evaluation of the role of CYP6B cytochrome P450s in pyrethroid resistant Australian Helicoverpa armigera.Semantic proximity Read ↗

Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.Semantic proximity Read ↗

The same amino acid substitution in orthologous esterases confers organophosphate resistance on the house fly and a blowflySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.