Article
A single p450 allele associated with insecticide resistance in Drosophila.
Science (New York, N.Y.) - 27 Sept 2002
Daborn P J, Yen J L, Bogwitz M R, Le Goff G, Feil E, Jeffers S, Tijet N, Perry T, Heckel D, Batterham P, Feyereisen R, Wilson T G, ffrench-Constant R H
Abstract excerpt
Insecticide resistance is one of the most widespread genetic changes caused by human activity, but we still understand little about the origins and spread of resistant alleles in global populations of insects. Here, via microarray analysis of all P450s in Drosophila melanogaster, we show that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a single cytochrome P450 gene, Cyp6g1....
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