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Article

A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997

Newcomb R D, Campbell P M, Ollis D L, Cheah E, Russell R J, Oakeshott J G

Abstract excerpt

Resistance to organophosphorus (OP) insecticides is associated with decreased carboxylesterase activity in several insect species. It has been proposed that the resistance may be the result of a mutation in a carboxylesterase that simultaneously reduces its carboxylesterase activity and confers an OP hydrolase activity (the "mutant ali-esterase hypothesis"). In the sheep blowfly, Lucilia cuprina, the association...

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Identifiers

PMID: 9207114
DOI: 10.1073/pnas.94.14.7464
PMCID: PMC23844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly.PMID 9207114Read ↗

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