Article
Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway.
Mechanisms of development - 1 Apr 2002
Tadokoro Yuko, Yomogida Kentaro, Ohta Hiroshi, Tohda Akira, Nishimune Yoshitake
Abstract excerpt
Stem cell regulatory mechanisms are difficult to study because self-renewal and production of differentiated progeny, which are both strictly controlled, occur simultaneously in these cells. To focus on the self-renewal mechanism alone, we investigated the behavior of germinal stem cells (GSCs) in progeny-deficient testes with defective GSC differentiation. In these testes, we found that the proliferation of...
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