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Article

Long-term proliferation in culture and germline transmission of mouse male germline stem cells.

Biology of reproduction - 1 Aug 2003

Kanatsu-Shinohara Mito, Ogonuki Narumi, Inoue Kimiko, Miki Hiromi, Ogura Atsuo, Toyokuni Shinya, Shinohara Takashi

Abstract excerpt

Spermatogenesis is a complex process that originates in a small population of spermatogonial stem cells. Here we report the in vitro culture of spermatogonial stem cells that proliferate for long periods of time. In the presence of glial cell line-derived neurotrophic factor, epidermal growth factor, basic fibroblast growth factor, and leukemia inhibitory factor, gonocytes isolated from neonatal mouse testis...

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Source

Identifiers

PMID: 12700182
DOI: 10.1095/biolreprod.103.017012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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