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A Val227Ala polymorphism in the peroxisome proliferator activated receptor α (<i>PPARα</i>) gene is associated with variations in serum lipid levels

1 Mar 2002

Abstract excerpt

Peroxisome proliferator activated receptors (PPARs) are ligand activated transcription factors that belong to the nuclear receptor superfamily.1, 2 PPARs regulate gene transcription by heterodimerising with retinoic X receptors and binding to DNA sequences, termed PPAR response elements (PPRE), in the promoters of target genes.2, 3 Three different PPAR genes (α, δ/β, and γ), each displaying distinct tissue and...

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PMID: 11897821
DOI: 10.1136/jmg.39.3.189

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