Article
p53, K-ras, c-kit and beta-catenin gene mutations in sinonasal NK/T-cell lymphoma in Korea and Japan.
Oncology reports - 1 Feb 2005
Hongyo Tadashi, Hoshida Yoshihiko, Nakatsuka Shin-Ichi, Syaifudin Mukh, Kojya Shizuo, Yang Woo-Ick, Min Yoo-Hong, Chan Heekyung, Kim Chan Hwan, Harabuchi Yasuaki, Himi Tetsuo, Inuyama Masao, Aozasa Katsuyuki, Nomura Taisei
Abstract excerpt
Mutations of p53, K-ras, c-kit, and beta-catenin gene were examined in 100 cases of sinonasal NK/T-cell lymphoma (NKTCL) from Korea and Japan. Age of patients ranged from 12 to 72 (median 41.0) in Korea and 27 to 82 (median 61.0) years in Japan. Gene mutations were analyzed on paraffin-embedded specimens by PCR-SSCP followed by direct sequencing. p53 is a well-known tumor suppressor gene. c-kit gene encodes a...
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