Article
Renal neoplasias in patients receiving dialysis and renal transplantation: clinico-pathological features and p53 gene mutations.
Transplantation - 15 Aug 1999
Hoshida Y, Nakanishi H, Shin M, Satoh T, Hanai J, Aozasa K
Abstract excerpt
BACKGROUND: In Japan, the relative risk for renal cell carcinoma (RCC) in renal transplants was about 80-fold higher than that in the general population. Depressed immune surveillance due to the use of immunosuppressive agents was considered to cause cancer. Before renal transplantation, a vast majority of patients received hemodialysis, a known causative factor for acquired cystic disease of kidney (ACDK)....
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