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Article

Selectionism and neutralism in molecular evolution.

Molecular biology and evolution - 1 Dec 2005

Nei Masatoshi

Abstract excerpt

Charles Darwin proposed that evolution occurs primarily by natural selection, but this view has been controversial from the beginning. Two of the major opposing views have been mutationism and neutralism. Early molecular studies suggested that most amino acid substitutions in proteins are neutral or nearly neutral and the functional change of proteins occurs by a few key amino acid substitutions. This suggestion...

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Identifiers

PMID: 16120807
DOI: 10.1093/molbev/msi242
PMCID: PMC1513187

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