Molecular analysis of mitochondrial DNA mutations from bleomycin-treated rats.

doi:10.1016/s0027-5107(01)00270-6

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Article

Molecular analysis of mitochondrial DNA mutations from bleomycin-treated rats.

Mutation research - 20 Mar 2002

Khaidakov Magomed, Manjanatha Mugimane G, Aidoo Anane

Abstract excerpt

In our previous studies, we have shown the mutagenicity of bleomycin (BLM) at the nuclear hprt locus. In the present study we have analyzed mutagenic effects of BLM in mitochondrial DNA (mtDNA) using short extension-PCR (SE-PCR) method for detection of low-copy deletions. Fisher 344 rats were treated with a single dose of BLM and total DNA preparations from splenic lymphocytes were processed in SE-PCR assay....

Topics

Animals
Antimetabolites, Antineoplastic
Base Sequence
Bleomycin
Cloning, Molecular
DNA, Mitochondrial
Gene Deletion
Genetic Variation
Hypoxanthine Phosphoribosyltransferase
Mutagens
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Polymerase Chain Reaction

Rats

Rats, Inbred F344

Repetitive Sequences, Nucleic Acid

Sequence Deletion

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 11890929
DOI: 10.1016/s0027-5107(01)00270-6

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