Article
Genetic alterations in differentiated thyroid cancers.
Endocrine, metabolic & immune disorders drug targets - 1 Sept 2009
Salehian Behrouz, Liu Zhong
Abstract excerpt
Differentiated thyroid cancers are the predominant malignancies of the thyroid. Due to advances in the understanding of the activation of the cell proliferation pathway at a molecular level, multiple genetic alterations have been linked to the development of thyroid carcinogenesis. Although the genetic alterations can be categorized into 7 categories, the BRAF mutation, RET/PTC, Pax8/PPARGamma, and dysfunctional...
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