Loss of one allele of the p53 gene in the lens epithelial tumor in transgenic mice suppresses apoptosis induced by a topoisomerase I inhibitor (CPT-11).

doi:10.1016/s0304-3835(02)00008-3

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Loss of one allele of the p53 gene in the lens epithelial tumor in transgenic mice suppresses apoptosis induced by a topoisomerase I inhibitor (CPT-11).

Cancer letters - 28 May 2002

Nakajima Yasuo, Nakamura Takafumi, Enomoto Takayuki, Murata Yuji

Abstract excerpt

To examine whether CPT-11 can induce apoptosis in the mouse lens tumor, it was administered to pregnant alphaT3 mice, which developed epithelial tumors in the lens during the perinatal stage. Three different p53 genotypes were generated to analyze the influence of p53 status on tumor cells under chemotherapy. On day 16--17 of gestation, alphaT3 mice received an i.p. injection of CPT-11, and fetal lens tumors were...

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Loss of one allele of the p53 gene in the lens epithelial tumor in transgenic mice suppresses apoptosis induced by a topoisomerase I inhibitor (CPT-11).

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