Article
Hereditary hemochromatosis in a Brazilian university hospital in São Paulo State (1990-2000).
Genetics and molecular research : GMR - 31 Mar 2005
Martinelli Ana L C, Filho Rui, Cruz Samantha, Franco Rendrik, Tavella Marli, Secaf Marie, Ramalho Leandra, Zucoloto Sergio, Rodrigues Sandra, Zago Marcos
Abstract excerpt
Hereditary hemochromatosis (HH) is the most common genetic disease among individuals of European descent. Two mutations (845G-->A, C282Y and 187C-->G, H63D) in the hemochromatosis gene (HFE gene) are associated with HH. About 85-90% of patients of northern European descent with HH are C282Y homozygous. The prevalence of HH in the Brazilian population, which has a very high level of racial admixture, is unknown....
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