Article
High serum enalaprilat in chronic renal failure.
Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Dec 2001
Elung-Jensen T, Heisterberg J, Kamper A L, Sonne J, Strandgaard S, Larsen N E
Abstract excerpt
BACKGROUND: Most angiotensin-converting enzyme (ACE) inhibitors and their metabolites are excreted renally and doses should hence be reduced in renal insufficiency. We studied whether the dosage of enalapril in daily clinical practice is associated with drug accumulation of enalaprilat in chronic renal failure. METHODS: Fifty nine out-patients with plasma creatinine >150 micromol/L and chronic antihypertensive...
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