Article
Mutations in the occQ operator that decrease OccR-induced DNA bending do not cause constitutive promoter activity.
The Journal of biological chemistry - 3 May 2002
Akakura Reiko, Winans Stephen C
Abstract excerpt
OccR is a LysR-type transcriptional regulator of Agrobacterium tumefaciens that positively regulates the octopine catabolism operon of the Ti plasmid. Positive control of the occ genes occurs in response to octopine, a metabolite released from plant tumors. Octopine causes DNA-bound OccR to undergo a conformational change from an inactive to an active state; this change is marked by a decrease in footprint length...
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