Article
DNAase I hypersensitive site 3' to the beta-globin gene cluster contains a TAA insertion specific for beta(S)-Benin haplotype.
Haematologica - 1 Mar 2002
Bordin Silvana, Crespi Vanessa G, Duarte Adriana S S, Bassères Daniela S, Melo Mônica B, Vieira Alexandra P Zilli, Saad Sara T O, Costa Fernando F
Abstract excerpt
BACKGROUND AND OBJECTIVES: Analysis of DNA polymorphic sites is a powerful tool for detection of gene flow in human evolutionary studies and to trace genetic background associated with abnormal genes. The beta-globin locus contains more than 20 single-base restriction fragment length polymorphism (RFLP) sites spanning over 80 kb on chromosome 11. Far downstream of the expressed genes, there is a hypersensitive...
Read the complete abstract on PubMedTopics
- AT Rich Sequence
- Anemia, Sickle Cell
- Base Sequence
- Binding Sites
- Deoxyribonuclease I
- Genetic Variation