Article
Mutations of the cationic trypsinogen gene in hereditary and non-hereditary pancreatitis.
Digestion - 1 Jan 2001
O'Reilly D A, Yang B M, Creighton J E, Demaine A G, Kingsnorth A N
Abstract excerpt
BACKGROUND/AIMS: Mutations in the cationic trypsinogen gene have been detected in patients with hereditary pancreatitis (HP). This study investigates the prevalence of the R122H, N29I, A16V and -28delTCC mutations in the common, non-hereditary forms of chronic pancreatitis and in a HP family. METHODS: DNA was prepared from blood samples of 53 patients with chronic pancreatitis (36 alcoholic, 14 idiopathic and 3...
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