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Article

Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map.

Genomics - 1 Mar 2002

Hewett Duncan, Samuelsson Lena, Polding Joanne, Enlund Fredrik, Smart Devi, Cantone Kathryn, See Chee Gee, Chadha Sapna, Inerot Annica, Enerback Charlotta, Montgomery Doug, Christodolou Chris, Robinson Phil, Matthews Paul, Plumpton Mary, Wahlstrom Jan, Swanbeck Gunnar, Martinsson Tommy, Roses Allen, Riley John, Purvis Ian

Abstract excerpt

Psoriasis is a chronic inflammatory disease of the skin with both genetic and environmental risk factors. Here we describe the creation of a single-nucleotide polymorphism (SNP) map spanning 900-1200 kb of chromosome 3q21, which had been previously recognized as containing a psoriasis susceptibility locus, PSORS5. We genotyped 644 individuals, from 195 Swedish psoriatic families, for 19 polymorphisms. Linkage...

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Identifiers

PMID: 11863360
DOI: 10.1006/geno.2002.6720

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