Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polyglycylation domain of beta-tubulin maintains axonemal architecture and affects cytokinesis in Tetrahymena.

Nature cell biology - 1 Mar 2002

Thazhath Rupal, Liu Chengbao, Gaertig Jacek

Abstract excerpt

Polyglycylation occurs through the post-translational addition of a polyglycine peptide to the gamma-carboxyl group of glutamic acids near the C terminus of alpha- and beta-tubulin, and has been found only in cells with axonemes, from protists to humans. In Tetrahymena thermophila, multiple sites of polyglycylation on alpha-tubulin are dispensable. By contrast, mutating similar sites on beta-tubulin has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation
Share to Microscopy, Electron
Share to Microscopy, Fluorescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microtubules

Share to Protein Processing, Post-Translational

Share to Protozoan Proteins

Share to Tetrahymena thermophila

Share to Tubulin

Source

Identifiers

PMID: 11862218
DOI: 10.1038/ncb764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polyglycylation domain of beta-tubulin maintains axonemal architecture and affects cytokinesis in Tetrahymena.PMID 11862218Read ↗

Polyglycylation of tubulin is essential and affects cell motility and division in Tetrahymena thermophila.Semantic proximity Read ↗

Tetrahymena thermophila contains a conventional gamma-tubulin that is differentially required for the maintenance of different microtubule-organizing centers.Semantic proximity Read ↗

Both carboxy-terminal tails of alpha- and beta-tubulin are essential, but either one will suffice.Semantic proximity Read ↗

Tubulin polyglutamylase: isozymic variants and regulation during the cell cycle in HeLa cells.Semantic proximity Read ↗

Tubulin polyglutamylation regulates axonemal motility by modulating activities of inner-arm dyneins.Semantic proximity Read ↗

A beta-tubulin mutation selectively uncouples nuclear division and cytokinesis in Tetrahymena thermophila.Semantic proximity Read ↗

Mutations of tubulin glycylation sites reveal cross-talk between the C termini of alpha- and beta-tubulin and affect the ciliary matrix in Tetrahymena.Semantic proximity Read ↗

Electrostatic interaction between polyglutamylated tubulin and the nexin-dynein regulatory complex regulates flagellar motility.Semantic proximity Read ↗

Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertilitySemantic proximity Read ↗

Cell context-specific effects of the beta-tubulin glycylation domain on assembly and size of microtubular organelles.Semantic proximity Read ↗

Cytoskeleton: functions for tubulin modifications at last.Semantic proximity Read ↗

Roles of beta-tubulin residues Ala428 and Thr429 in microtubule formation in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.