Article
Tubulin polyglutamylase: isozymic variants and regulation during the cell cycle in HeLa cells.
Journal of cell science - 1 Dec 1999
Regnard C, Desbruyères E, Denoulet P, Eddé B
Abstract excerpt
Polyglutamylation is a posttranslational modification of tubulin that is very common in neurons and ciliated or flagellated cells. It was proposed to regulate the binding of microtubule associated proteins (MAPs) and molecular motors as a function of the length of the polyglutamyl side-chain. Though much less common, this modification of tubulin also occurs in proliferating cells like HeLa cells where it is...
Topics
- Animals
- Brain
- Cell Cycle
- Cell Division
- Centrioles
- Docetaxel
- G2 Phase
- Gene Expression Regulation, Enzymologic
- Genetic Variation
- HeLa Cells
- Humans
- Hydroxyurea
- Isoenzymes
- Mice
- Nocodazole
- Paclitaxel
- Peptide Synthases
- Polyglutamic Acid