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Article

Polyglycylation of tubulin is essential and affects cell motility and division in Tetrahymena thermophila.

The Journal of cell biology - 29 May 2000

Xia L, Hai B, Gao Y, Burnette D, Thazhath R, Duan J, Bré M H, Levilliers N, Gorovsky M A, Gaertig J

Abstract excerpt

We analyzed the role of tubulin polyglycylation in Tetrahymena thermophila using in vivo mutagenesis and immunochemical analysis with modification-specific antibodies. Three and five polyglycylation sites were identified at glutamic acids near the COOH termini of alpha- and beta-tubulin, respectively. Mutants lacking all polyglycylation sites on alpha-tubulin have normal phenotype, whereas similar sites on...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10831613
DOI: 10.1083/jcb.149.5.1097
PMCID: PMC2174830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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